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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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CC-1088 (Code C2210)

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Terms & Properties

Preferred Name: CC-1088

Definition: An analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). (NCI04)

NCI-GLOSS Definition: A drug that is being studied in the treatment of cancer. It is similar but not identical to thalidomide. CC-1088 belongs to the family of drugs called angiogenesis inhibitors.

Label: CC-1088

NCI Thesaurus Code: C2210 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879595  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 38051
PDQ Open Trial Search ID 38051 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879595

Other Properties:
     Name Value (qualifiers indented underneath)
code C2210
Legacy_Concept_Name CC-1088
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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