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Version: 17.06d (Release date: 2017-06-26)
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Sodium Borocaptate (Code C2208)

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Terms & Properties

Preferred Name: Sodium Borocaptate

Definition: A boron-carrying compound. After parenteral administration, sodium borocaptate accumulates preferentially in tumor cells. When exposed to neutron irradiation, borocaptate absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues. (NCI04)

NCI-GLOSS Definition: A substance used in a type of radiation therapy called boron neutron capture therapy. Sodium borocaptate is injected into a vein and becomes concentrated in tumor cells. The patient then receives radiation treatment with atomic particles called neutrons. The neutrons react with the boron in sodium borocaptate and make radioactive particles that kill the tumor cells without harming normal cells.

Label: Sodium Borocaptate

NCI Thesaurus Code: C2208 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0127575  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Borocaptate Sodium
Borocarpin
BSH
Sodium Borocaptate
sodium borocaptate

External Source Codes: 
CAS Registry Number 12448-24-7 (see NLM ChemIDplus info)
CAS Registry Number 80-17-1 (see NLM ChemIDplus info)
NSC Code 643 (see NCI DTP info)
PDQ Closed Trial Search ID 306451
PDQ Open Trial Search ID 306451 (check for NCI PDQ open clinical trial info)
UMLS CUI C0127575

Other Properties:
     Name Value (qualifiers indented underneath)
code C2208
Legacy_Concept_Name Borocaptate_Sodium
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2208

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