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Version: 17.06d (Release date: 2017-06-26)
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Acridine Carboxamide (Code C2203)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Acridine Carboxamide

Definition: A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.

Label: Acridine Carboxamide

NCI Thesaurus Code: C2203 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0919282  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Acridine Carboxamide
acridine carboxamide
DACA
N-(2-(Dimehtylamino)ethyl)acridine-4-carboxamide
NSC-601316
SN 22995
XR5000

External Source Codes: 
FDA UNII Code 0N3V8R4E13
PDQ Closed Trial Search ID 37776
PDQ Open Trial Search ID 37776 (check for NCI PDQ open clinical trial info)
UMLS CUI C0919282

Other Properties:
     Name Value (qualifiers indented underneath)
code C2203
Contributing_Source FDA
Legacy_Concept_Name Acridine_Carboxamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2203

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