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Version: 17.06d (Release date: 2017-06-26)
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Tacedinaline (Code C2202)

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Terms & Properties

Preferred Name: Tacedinaline

Definition: An orally bioavailable substituted benzamide derivative with potential antineoplastic activity. Tacedinaline inhibits histone deacetylation, which may result in histone hyperacetylation, followed by the induction of differentiation, the inhibition of cell proliferation, and apoptosis in susceptible tumor cell populations.

NCI-GLOSS Definition: A substance being studied in the treatment of non-small cell lung cancer.

Label: Tacedinaline

NCI Thesaurus Code: C2202 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0217598  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(Acetylamino)-N-(2-aminophenyl)benzamide
Acetyldinaline
CI-994
GOE5549
N-acetyldinaline
N-acetyl Dinaline
PD 123654
TACEDINALINE
Tacedinaline

External Source Codes: 
CAS Registry Number 112522-64-2 (see NLM ChemIDplus info)
FDA UNII Code UMF554N5FG
PDQ Closed Trial Search ID 37825
PDQ Open Trial Search ID 37825 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 18497959 (see PubMed Primary Reference info)
UMLS CUI C0217598

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H15N3O2
code C2202
Contributing_Source FDA
Legacy_Concept_Name Acetyldinaline
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2202

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