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Version: 16.11d (Release date: 2016-11-28)
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Alfentanil Hydrochloride (Code C220)

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Terms & Properties

Preferred Name: Alfentanil Hydrochloride

Definition: The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited.

Label: Alfentanil Hydrochloride

NCI Thesaurus Code: C220 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700562  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alfenta
ALFENTANIL HYDROCHLORIDE
Alfentanil Hydrochloride
Rapifen

External Source Codes: 
CAS Registry Number 70879-28-6 (see NLM ChemIDplus info)
FDA UNII Code 11S92G0TIW
PDQ Closed Trial Search ID 42783
PDQ Open Trial Search ID 42783 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700562

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C21H32N6O3.ClH.H2O
code C220
Contributing_Source FDA
Legacy_Concept_Name Alfentanil_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C220

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