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Version: 16.10e (Release date: 2016-10-31)
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Sorafenib Tosylate (Code C2194)

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Terms & Properties

Preferred Name: Sorafenib Tosylate

Definition: The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.

NCI-GLOSS Definition: A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Sorafenib Tosylate

Label: Sorafenib Tosylate

NCI Thesaurus Code: C2194 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1676709  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate
BAY 43-9006 Tosylate
BAY 54-9085
Nexavar
sorafenib
Sorafenib Tosylate
SORAFENIB TOSYLATE
sorafenib tosylate

External Source Codes: 
CAS Registry Number 475207-59-1 (see NLM ChemIDplus info)
FDA UNII Code 5T62Q3B36J
ChEBI ID CHEBI:50928 (see ChEBI info)
NSC Code 724772 (see NCI DTP info)
PDQ Closed Trial Search ID 299013
PDQ Open Trial Search ID 299013 (check for NCI PDQ open clinical trial info)
UMLS CUI C1676709

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Advanced renal cell carcinoma; Metastatic Colorectal Cancer
Accepted_Therapeutic_Use_For Major Depressive Disorder
Chemical_Formula C21H16ClF3N4O3.C7H8O3S
code C2194
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BAY_43-9006
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2194

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