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Version: 16.12d (Release date: 2016-12-27)
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Lopinavir (Code C2095)

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Terms & Properties

Preferred Name: Lopinavir

Definition: A peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related drug ritonavir.

NCI-GLOSS Definition: A drug used with another drug, called ritonavir, to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Lopinavir blocks the ability of HIV to make copies of itself and may help some anticancer drugs work better. It is a type of anti-HIV agent and a type of protease inhibitor.

Display Name: Lopinavir

Label: Lopinavir

NCI Thesaurus Code: C2095 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0674432  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABT-378/r
Lopinavir
LOPINAVIR
lopinavir

External Source Codes: 
CAS Registry Number 192725-17-0 (see NLM ChemIDplus info)
FDA UNII Code 2494G1JF75
PDQ Closed Trial Search ID 540623
PDQ Open Trial Search ID 540623 (check for NCI PDQ open clinical trial info)
UMLS CUI C0674432

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C37H48N4O5
code C2095
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lopinavir
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2095

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