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Version: 17.06d (Release date: 2017-06-26)
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Acyclovir (Code C205)

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Terms & Properties

Preferred Name: Acyclovir

Definition: A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. After conversion in vivo to the active metabolite acyclovir triphosphate by viral thymidine kinase, acyclovir competitively inhibits viral DNA polymerase by incorporating into the growing viral DNA chain and terminating further polymerization.

NCI-GLOSS Definition: A substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals.

Display Name: Acyclovir

Label: Acyclovir

NCI Thesaurus Code: C205 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0001367  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
9-[(2-Hydroxyethoxy)-methyl]guanine
9-[(2-Hydroxyethoxy)methyl]guanine
Acicloftal
Aciclovir
Aclovir
ACV
Acycloguanosine
Acyclovir
acyclovir
ACYCLOVIR
BW-248U
Cargosil
Virorax
Wellcome-248U
Zovirax

External Source Codes: 
CAS Registry Number 59277-89-3 (see NLM ChemIDplus info)
FDA UNII Code X4HES1O11F
ChEBI ID CHEBI:2453 (see ChEBI info)
NSC Code 335752 (see NCI DTP info)
NSC Code 645011 (see NCI DTP info)
PDQ Closed Trial Search ID 39134
PDQ Open Trial Search ID 39134 (check for NCI PDQ open clinical trial info)
UMLS CUI C0001367

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H11N5O3
code C205
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Acyclovir
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C205

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