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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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ISIS 2503 (Code C2024)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ISIS 2503

Definition: A synthetic oligodeoxynucleotide. Functioning as an anti-sense agent, it hybridizes to the translation initiation region of the human mRNA for the oncogene H-Ras. ISIS 2503 selectively inhibits the expression of H-Ras, and may inhibit the growth of some Ras-dependent tumor cells. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer.

Label: ISIS 2503

NCI Thesaurus Code: C2024 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879385  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
H-RAS Antisense
ISIS-2503
ISIS 2503

External Source Codes: 
NSC Code 718878 (see NCI DTP info)
PDQ Closed Trial Search ID 37795
PDQ Open Trial Search ID 37795 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879385

Other Properties:
     Name Value (qualifiers indented underneath)
code C2024
Legacy_Concept_Name ISIS_2503
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2024

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