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Version: 17.06d (Release date: 2017-06-26)
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Aclarubicin (Code C202)

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Terms & Properties

Preferred Name: Aclarubicin

Definition: An oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine. This agent is less cardiotoxic than doxorubicin and daunorubicin.

Label: Aclarubicin

NCI Thesaurus Code: C202 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0001143  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid methyl ester
1-naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5, 7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl) -alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-, methyl ester,(1R-(1alpha,2beta,4beta))-(9CI)
Aclacinomycin
Aclacinomycin-A
Aclacinomycin A
Aclarubicin
ACLARUBICIN
ACM-A
Antibiotic MA144-A1
MA144-A1

External Source Codes: 
CAS Registry Number 57576-44-0 (see NLM ChemIDplus info)
FDA UNII Code 74KXF8I502
NSC Code 240619 (see NCI DTP info)
NSC Code 208734 (see NCI DTP info)
PDQ Closed Trial Search ID 39131
PDQ Open Trial Search ID 39131 (check for NCI PDQ open clinical trial info)
UMLS CUI C0001143

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C42H53NO15
code C202
Contributing_Source FDA
Legacy_Concept_Name Aclarubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C202

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