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Version: 17.06d (Release date: 2017-06-26)
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Abarelix (Code C2015)

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Terms & Properties

Preferred Name: Abarelix

Definition: A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.

NCI-GLOSS Definition: A drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called gonadotropin-releasing hormone (GnRH) antagonists.

Display Name: Abarelix

Label: Abarelix

NCI Thesaurus Code: C2015 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1174732  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Abarelix
abarelix
ABARELIX
Plenaxis
PPI-149
R-3827

External Source Codes: 
CAS Registry Number 183552-38-7 (see NLM ChemIDplus info)
FDA UNII Code W486SJ5824
ChEBI ID CHEBI:337298 (see ChEBI info)
PDQ Closed Trial Search ID 415570
PDQ Open Trial Search ID 415570 (check for NCI PDQ open clinical trial info)
UMLS CUI C1174732

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Prostate Cancer
Chemical_Formula C72H95ClN14O14
code C2015
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Abarelix
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2015

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