|Matuzumab (Code C2012)|
|Terms & Properties|
Preferred Name: Matuzumab
Definition: A humanized monoclonal antibody with antineoplastic activity. Matuzumab binds the epidermal growth factor receptor (EGFR) with high affinity, competitively blocking natural ligand binding and inhibiting receptor-mediated downstream signalling, resulting in impaired tumor cell proliferation.
NCI-GLOSS Definition: A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. EMD 72000 binds to the epithelial growth factor receptor (EGFR) on tumor cells and blocks growth signals.
NCI Metathesaurus Link: C1328134 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||350433|
|PDQ Open Trial Search ID||350433 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Amino Acid, Peptide, or Protein|
Additional Concept Data:
|Defined Fully by Roles: No|