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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Matuzumab (Code C2012)

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Terms & Properties

Preferred Name: Matuzumab

Definition: A humanized monoclonal antibody with antineoplastic activity. Matuzumab binds the epidermal growth factor receptor (EGFR) with high affinity, competitively blocking natural ligand binding and inhibiting receptor-mediated downstream signalling, resulting in impaired tumor cell proliferation.

NCI-GLOSS Definition: A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. EMD 72000 binds to the epithelial growth factor receptor (EGFR) on tumor cells and blocks growth signals.

Label: Matuzumab

NCI Thesaurus Code: C2012 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328134  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EMD 72000

External Source Codes: 
PDQ Closed Trial Search ID 350433
PDQ Open Trial Search ID 350433 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328134

Other Properties:
     Name Value (qualifiers indented underneath)
code C2012
Legacy_Concept_Name EMD_72000
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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