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Version: 17.06d (Release date: 2017-06-26)
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Acetylcysteine (Code C200)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Acetylcysteine

Definition: A synthetic N-acetyl derivative of the endogenous amino acid L-cysteine, a precursor of the antioxidant enzyme glutathione. Acetylcysteine regenerates liver stores of glutathione. This agent also reduces disulfide bonds in mucoproteins, resulting in liquification of mucus. Some evidence suggests that acetylcysteine may exert an anti-apoptotic effect due to its antioxidant activity, possibly preventing cancer cell development or growth. In addition, acetylcysteine has inhibited viral stimulation by reactive oxygen intermediates, thereby producing antiviral activity in HIV patients. (NCI04)

NCI-GLOSS Definition: A drug usually used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen.

Display Name: Acetylcysteine

Label: Acetylcysteine

NCI Thesaurus Code: C200 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0001047  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Acetadote
Acetylcysteine
acetylcysteine
ACETYLCYSTEINE
Airbron
Broncholysin
Brunac
Fabrol
Fluatox
Fluimucetin
Fluimucil
Fluprowit
L-Alpha-acetamido-beta-mercaptopropionic Acid
Mucocedyl
Mucolator
Mucolyticum
Mucomyst
Mucosolvin
Muco Sanigen
Mucret
N-acetyl-3-mercaptoalanine
N-acetyl-L-cysteine
N-Acetyl-L-cysteine
N-Acetylcysteine
N-acetylcysteine
N-Acetyl Cysteine
NAC
Neo-Fluimucil
Parvolex
Respaire
Tixair

External Source Codes: 
CAS Registry Number 616-91-1 (see NLM ChemIDplus info)
FDA UNII Code WYQ7N0BPYC
ChEBI ID CHEBI:28939 (see ChEBI info)
NSC Code 111180 (see NCI DTP info)
PDQ Closed Trial Search ID 39130
PDQ Open Trial Search ID 39130 (check for NCI PDQ open clinical trial info)
UMLS CUI C0001047

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acetaminophen Overdose
Chemical_Formula C5H9NO3S
code C200
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Acetylcysteine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C200

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