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Version: 17.12d (Release date: 2017-12-26)
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Sipuleucel-T (Code C1985)

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Terms & Properties

Preferred Name: Sipuleucel-T

Definition: A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI05)

NCI-GLOSS Definition: A drug used to treat prostate cancer that has spread. It is made from immune system cells collected from a patient with prostate cancer. The cells are treated with a protein that is made by combining a protein found on prostate cancer cells with a growth factor. When the cells are injected back into the patient, they may stimulate T cells to kill prostate cancer cells. Provenge is a type of vaccine and a type of cellular adoptive immunotherapy.

Display Name: Sipuleucel-T

Label: Sipuleucel-T

NCI Thesaurus Code: C1985 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1706668  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
APC8015 Vaccine
PA2024 (PAP/GM-CSF)-Loaded Dendritic Cell Vaccine

External Source Codes: 
CAS Registry Number 917381-47-6 (see NLM ChemIDplus info)
FDA UNII Code 8Q622VDR18
NSC Code 720270 (see NCI DTP info)
PDQ Closed Trial Search ID 38038
PDQ Open Trial Search ID 38038 (check for NCI PDQ open clinical trial info)
UMLS CUI C1706668

Other Properties:
     Name Value (qualifiers indented underneath)
code C1985
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name APC8015_Vaccine
Semantic_Type Cell
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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