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Version: 16.10e (Release date: 2016-10-31)
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Acetaminophen (Code C198)

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Terms & Properties

Preferred Name: Acetaminophen

Definition: A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold. The antipyretic activity may result from inhibition of prostaglandin synthesis and release in the central nervous system (CNS) and prostaglandin-mediated effects on the heat-regulating center in the anterior hypothalamus.

NCI-GLOSS Definition: A drug that reduces pain and fever (but not inflammation). It belongs to the family of drugs called analgesics.

Display Name: Acetaminophen

Label: Acetaminophen

NCI Thesaurus Code: C198 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0000970  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Hydroxyacetanilide
Acetaminophen
ACETAMINOPHEN
acetaminophen
APAP
N-(4-Hydroxyphenyl)acetamide
Paracetamol
Tylenol

External Source Codes: 
CAS Registry Number 103-90-2 (see NLM ChemIDplus info)
FDA UNII Code 362O9ITL9D
ChEBI ID CHEBI:46195 (see ChEBI info)
NSC Code 109028 (see NCI DTP info)
NSC Code 3991 (see NCI DTP info)
PDQ Closed Trial Search ID 39129
PDQ Open Trial Search ID 39129 (check for NCI PDQ open clinical trial info)
UMLS CUI C0000970

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C8H9NO2
code C198
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Acetaminophen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C198

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