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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interferon Alfa-2a (Code C1952)

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Terms & Properties

Preferred Name: Recombinant Interferon Alfa-2a

Definition: A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04)

Display Name: Recombinant Interferon Alfa-2a

Label: Recombinant Interferon Alfa-2a

NCI Thesaurus Code: C1952 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0021734  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha 2 Interferon
IFN-Alpha 2
IFN alpha-2A
INTERFERON ALFA-2A
Interferon alfa 2a
Laroferon
Recombinant Interferon Alfa-2a
Recombinant Interferon Alpha-2a
rHuIFN-a 2a
Roceron-A
Roferon A

External Source Codes: 
CAS Registry Number 76543-88-9 (see NLM ChemIDplus info)
FDA UNII Code 47RRR83SK7
NSC Code 367982 (see NCI DTP info)
PDQ Closed Trial Search ID 467189
PDQ Open Trial Search ID 467189 (check for NCI PDQ open clinical trial info)
UMLS CUI C0021734

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic phase Philadelphia chromosome-positive chronic myelogenous leukemia; hairy cell leukemia; chronic hepatitis C; AIDs-related Kaposis sarcoma; bladder; ovarian; cervical cancer; non-Hodgkins lymphoma; renal cell carcinoma; melanoma.
code C1952
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Interferon_Alpha-2a
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1952

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