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Version: 17.06d (Release date: 2017-06-26)
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3-Deazauridine (Code C193)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 3-Deazauridine

Definition: A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position. 3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.(NCI04)

Label: 3-Deazauridine

NCI Thesaurus Code: C193 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0000399  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2(1H)-pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl

External Source Codes: 
CAS Registry Number 23205-42-7 (see NLM ChemIDplus info)
FDA UNII Code 263CU738ZY
NSC Code 126849 (see NCI DTP info)
PDQ Closed Trial Search ID 39208
PDQ Open Trial Search ID 39208 (check for NCI PDQ open clinical trial info)
UMLS CUI C0000399

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H13NO6
code C193
Contributing_Source FDA
Legacy_Concept_Name _3-Deazauridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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