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Version: 16.11d (Release date: 2016-11-28)
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Mesna (Code C192)

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Terms & Properties

Preferred Name: Mesna

Definition: A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)

NCI-GLOSS Definition: A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.

Display Name: Mesna

Label: Mesna

NCI Thesaurus Code: C192 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0000294  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Mercaptoethanesulfonate, Sodium Salt
2-Mercaptoethanesulfonic Acid Sodium Salt
Ausobronc
D-7093
Filesna
Mercaptoethanesulfonate
Mercaptoethane Sulfonate
Mesna
MESNA
mesna
Mesnex
Mesnil
Mesnum
Mexan
Mistabron
Mistabronco
Mitexan
Mucofluid
Mucolene
Sodium 2-Mercaptoethanesulphonate
Sodium 2-Mercaptoethane Sulfonate
UCB 3983
Uromitexan
Ziken

External Source Codes: 
CAS Registry Number 19767-45-4 (see NLM ChemIDplus info)
FDA UNII Code NR7O1405Q9
NSC Code 113891 (see NCI DTP info)
PDQ Closed Trial Search ID 39759
PDQ Open Trial Search ID 39759 (check for NCI PDQ open clinical trial info)
UMLS CUI C0000294

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Ifosfamide-induced hemorrhagic cystitis, prophylaxis
Chemical_Formula C2H5O3S2.Na
code C192
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mesna
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C192

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