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Gonadotropin-releasing Hormone Analog (Code C1910)

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Terms & Properties

Preferred Name: Gonadotropin-releasing Hormone Analog

Definition: A synthetic analogue of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analogue mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analogue results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogues of GnRH have a stronger receptor binding affinity than the endogenous form.

NCI-GLOSS Definition: A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, gonadotropin-releasing hormone agonists cause the testicles to stop making testosterone. In women, they cause the ovaries to stop making estrogen and progesterone. Some gonadotropin-releasing hormone agonists are used to treat prostate cancer. Also called GnRH agonist, LH-RH agonist, and luteinizing hormone-releasing hormone agonist.

Display Name: Gonadotropin-releasing Hormone Analog

Label: Gonadotropin-releasing Hormone Analog

NCI Thesaurus Code: C1910 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1268900  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GnRH Agonist
GnRH Analog
gonadotropin-releasing hormone agonist
Gonadotropin-Releasing Hormone Agonist
Gonadotropin-releasing Hormone Analog
Gonadotropin-Releasing Hormone Analogue
LH-RH agonist
LH-RH Analogs
LHRH Agonist
luteinizing hormone-releasing hormone agonist
Luteinizing Hormone-Releasing Hormone Analog

External Source Codes: 
PDQ Closed Trial Search ID 42628
PDQ Open Trial Search ID 42628 (check for NCI PDQ open clinical trial info)
UMLS CUI C1268900

Other Properties:
     Name Value (qualifiers indented underneath)
code C1910
Contributing_Source CTRP
Legacy_Concept_Name Luteinizing_Hormone-releasing_Hormone_Agonist
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1910

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