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Version: 16.10e (Release date: 2016-10-31)
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Brostallicin (Code C1889)

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Terms & Properties

Preferred Name: Brostallicin

Definition: A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents.

Display Name: Brostallicin

Label: Brostallicin

NCI Thesaurus Code: C1889 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1122890  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(2-Bromoacrylamido)-N'''-(2-guanidinoethyl)-1,1',1',1'''-tetramethyl-N,4':N',4':N',4'''-quater(pyrrole-2-carboxamide)
Brostallicin
BROSTALLICIN
PNU-166196

External Source Codes: 
CAS Registry Number 203258-60-0 (see NLM ChemIDplus info)
FDA UNII Code RPC6R41K4I
PDQ Closed Trial Search ID 590644
PDQ Open Trial Search ID 590644 (check for NCI PDQ open clinical trial info)
UMLS CUI C1122890

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C30H35BrN12O5
code C1889
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Brostallicin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1889

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