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Version: 17.10e (Release date: 2017-10-30)
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Brostallicin (Code C1889)

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Terms & Properties

Preferred Name: Brostallicin

Definition: A synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents.

Display Name: Brostallicin

Label: Brostallicin

NCI Thesaurus Code: C1889 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1122890  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 203258-60-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 590644
PDQ Open Trial Search ID 590644 (check for NCI PDQ open clinical trial info)
UMLS CUI C1122890

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H35BrN12O5
code C1889
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Brostallicin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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