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Version: 17.06d (Release date: 2017-06-26)
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Epratuzumab (Code C1887)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Epratuzumab

Definition: A recombinant, humanized monoclonal antibody directed against CD22, a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells. After binding to CD22, epratuzumab's predominant antitumor activity appears to be mediated through antibody-dependent cellular cytotoxicity (ADCC).

Display Name: Epratuzumab

Label: Epratuzumab

NCI Thesaurus Code: C1887 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1120776  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Epratuzumab
EPRATUZUMAB
epratuzumab
hLL2
Humanized Anti-CD22 Monoclonal Antibody IgG1
LymphoCide

External Source Codes: 
CAS Registry Number 205923-57-5 (see NLM ChemIDplus info)
FDA UNII Code 3062P60MH9
NSC Code 716711 (see NCI DTP info)
PDQ Closed Trial Search ID 42234
PDQ Open Trial Search ID 42234 (check for NCI PDQ open clinical trial info)
UMLS CUI C1120776

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Systemic lupus erythematosus
code C1887
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Epratuzumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1887

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