|BAY 56-3722 (Code C1886)|
|Terms & Properties|
Preferred Name: BAY 56-3722
Definition: A water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood.
NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called camptothecins.
Label: BAY 56-3722
NCI Metathesaurus Link: C1101785 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||38705|
|PDQ Open Trial Search ID||38705 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Amino Acid, Peptide, or Protein|
Additional Concept Data:
|Defined Fully by Roles: No|