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Version: 17.06d (Release date: 2017-06-26)
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BAY 56-3722 (Code C1886)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BAY 56-3722

Definition: A water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood.

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called camptothecins.

Label: BAY 56-3722

NCI Thesaurus Code: C1886 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1101785  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BAY 38-3441
BAY 56-3722

External Source Codes: 
PDQ Closed Trial Search ID 38705
PDQ Open Trial Search ID 38705 (check for NCI PDQ open clinical trial info)
UMLS CUI C1101785

Other Properties:
     Name Value (qualifiers indented underneath)
code C1886
Legacy_Concept_Name BAY_56-3722
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1886

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