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Version: 17.06d (Release date: 2017-06-26)
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Brivudine Phosphoramidate (Code C1882)

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Terms & Properties

Preferred Name: Brivudine Phosphoramidate

Definition: A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active against tumor cells expressing high levels of thymidylate synthase (TS), brivudine is converted intracellularly by TS to bromovinyldeoxyuridine monophosphate (BVdUMP) which competes with the natural substrate, deoxyuridine monophosphate, for binding to TS. Unlike TS inhibitors, this agent is a reversible substrate for TS catalysis. Thus, TS retains activity and converts BVdUMP into cytotoxic metabolites. As key enzyme in the de novo synthesis of dTMP, TS is an enzyme critical to DNA biosynthesis and is overexpressed in many solid tumors.

NCI-GLOSS Definition: A substance that is being studied for its ability to make cancer cells respond to drugs to which they have become resistant. It is a type of nucleoside analog.

Label: Brivudine Phosphoramidate

NCI Thesaurus Code: C1882 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0964443  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate
Brivudine Phosphoramidate
BVdU Phosphoramidate
BVDU Prodrug
NB101.1
NB1011
Thymectacin

External Source Codes: 
PDQ Closed Trial Search ID 38549
PDQ Open Trial Search ID 38549 (check for NCI PDQ open clinical trial info)
UMLS CUI C0964443

Other Properties:
     Name Value (qualifiers indented underneath)
code C1882
Legacy_Concept_Name NB1011
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1882

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