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Version: 16.11d (Release date: 2016-11-28)
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Motexafin Gadolinium (Code C1881)

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Terms & Properties

Preferred Name: Motexafin Gadolinium

Definition: A synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating reactive oxygen species (ROS) intracellularly and lowering the tumor cell apoptotic threshold to ionizing radiation and chemotherapy. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It may make tumor cells more sensitive to radiation therapy, improve tumor images using magnetic resonance imaging (MRI), and kill cancer cells. It is a type of metalloporphyrin complex.

Display Name: Motexafin Gadolinium

Label: Motexafin Gadolinium

NCI Thesaurus Code: C1881 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0964264  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
API-GP3
Gadolinium Texaphyrin
gadolinium texaphyrin
Gd-Tex
Gd (III) Texaphryin
Motexafin Gadolinium
MOTEXAFIN GADOLINIUM
motexafin gadolinium
PCI-0120
Xcytrin

External Source Codes: 
CAS Registry Number 156436-89-4 (see NLM ChemIDplus info)
FDA UNII Code 6433A42F4F
ChEBI ID CHEBI:50161 (see ChEBI info)
ChEBI ID CHEBI:50162 (see ChEBI info)
NSC Code 695238 (see NCI DTP info)
PDQ Closed Trial Search ID 42391
PDQ Open Trial Search ID 42391 (check for NCI PDQ open clinical trial info)
UMLS CUI C0964264

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C48H66N5O10.2C2H3O2.Gd
code C1881
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Motexafin_Gadolinium
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1881

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