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Version: 16.11d (Release date: 2016-11-28)
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Canertinib Dihydrochloride (Code C1880)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Canertinib Dihydrochloride

Definition: The hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. Canertinib blocks the action of proteins called epidermal growth factor receptors, and may cause cancer cells to die. It is a type of tyrosine kinase inhibitor.

Display Name: Canertinib Dihydrochloride

Label: Canertinib Dihydrochloride

NCI Thesaurus Code: C1880 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1707132  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
canertinib
Canertinib Dihydrochloride
CANERTINIB DIHYDROCHLORIDE
canertinib dihydrochloride
CI-1033
N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide Dihydrochloride
PD-0183805-002B
PD183805

External Source Codes: 
CAS Registry Number 289499-45-2 (see NLM ChemIDplus info)
FDA UNII Code ICJ93X8X90
PDQ Closed Trial Search ID 38403
PDQ Open Trial Search ID 38403 (check for NCI PDQ open clinical trial info)
UMLS CUI C1707132

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C24H25ClFN5O3.2HCl
code C1880
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CI-1033
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1880

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