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Version: 17.06d (Release date: 2017-06-26)
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Darbepoetin Alfa (Code C1878)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Darbepoetin Alfa

Definition: A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. (NCI04)

NCI-GLOSS Definition: A substance made in the laboratory that stimulates the bone marrow to produce red blood cells. It belongs to the family of drugs called antianemics.

Display Name: Darbepoetin Alfa

Label: Darbepoetin Alfa

NCI Thesaurus Code: C1878 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0937950  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aranesp
Darbepoetin Alfa
DARBEPOETIN ALFA
darbepoetin alfa
NESP
Nespo
Novel Erythropoiesis Stimulating Protein

External Source Codes: 
CAS Registry Number 209810-58-2 (see NLM ChemIDplus info)
FDA UNII Code 15UQ94PT4P
NSC Code 729969 (see NCI DTP info)
PDQ Closed Trial Search ID 38676
PDQ Open Trial Search ID 38676 (check for NCI PDQ open clinical trial info)
UMLS CUI C0937950

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chemotherapy-induced anemia; chronic renal failure/insufficiency
code C1878
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Darbepoetin_Alfa
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1878

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