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Version: 16.11d (Release date: 2016-11-28)
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Cositecan (Code C1877)

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Terms & Properties

Preferred Name: Cositecan

Definition: A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.

NCI-GLOSS Definition: A drug being studied in the treatment of cancer. It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin.

Display Name: Cositecan

Label: Cositecan

NCI Thesaurus Code: C1877 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935985  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(4S)-4-Ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
BNP1350
Cositecan
COSITECAN
DB 172
Karenitecin
karenitecin

External Source Codes: 
CAS Registry Number 203923-89-1 (see NLM ChemIDplus info)
FDA UNII Code 24R60NVC41
NSC Code 710270 (see NCI DTP info)
PDQ Closed Trial Search ID 38211
PDQ Open Trial Search ID 38211 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935985

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C25H28N2O4Si
code C1877
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Karenitecin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1877

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