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Version: 17.06d (Release date: 2017-06-26)
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Lurtotecan Liposome (Code C1876)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Lurtotecan Liposome

Definition: A liposome-encapsulated formulation of lurtotecan with antineoplastic activity. Lurtotecan, a semisynthetic analogue of camptothecin, selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex during S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks. This ultimately results in an inhibition of DNA replication, inducing double-stranded DNA breakages, obstruction of RNA and protein synthesis and triggering apoptosis. Furthermore, this agent also stimulates degradation of topoisomerase I, likely mediated through ubiquitin-proteasomal pathway. Liposomal delivery of lurtotecan improves its penetration and delivery into tumors while lowering systemic side effects.

Label: Lurtotecan Liposome

NCI Thesaurus Code: C1876 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935959  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
liposomal lurtotecan
liposome, lurtotecan
Lurtotecan Liposome
NX211
OSI-211

External Source Codes: 
PDQ Closed Trial Search ID 43473
PDQ Open Trial Search ID 43473 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935959

Other Properties:
     Name Value (qualifiers indented underneath)
code C1876
Legacy_Concept_Name Lurtotecan_Liposome
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1876

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