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Version: 17.06d (Release date: 2017-06-26)
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Rebimastat (Code C1875)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Rebimastat

Definition: A sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called matrix metalloproteinase inhibitors (MMPIs).

Display Name: Rebimastat

Label: Rebimastat

NCI Thesaurus Code: C1875 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935902  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-275291
D2163
N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide
Rebimastat
REBIMASTAT

External Source Codes: 
CAS Registry Number 259188-38-0 (see NLM ChemIDplus info)
FDA UNII Code 1B47R6ZX4K
NSC Code 713763 (see NCI DTP info)
PDQ Closed Trial Search ID 38088
PDQ Open Trial Search ID 38088 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935902

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H41N5O5S
code C1875
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BMS-275291
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1875

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