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Version: 17.06d (Release date: 2017-06-26)
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Midostaurin (Code C1872)

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Terms & Properties

Preferred Name: Midostaurin

Definition: A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

NCI-GLOSS Definition: A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase inhibitors.

Display Name: Midostaurin

Label: Midostaurin

NCI Thesaurus Code: C1872 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0526371  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CGP41251
CGP 41251
Midostaurin
MIDOSTAURIN
midostaurin
N-Benzoyl-Staurosporine
N-benzoyl-staurosporine
N-Benzoylstaurosporine
PKC-412
PKC412
Rydapt

External Source Codes: 
CAS Registry Number 120685-11-2 (see NLM ChemIDplus info)
FDA UNII Code ID912S5VON
ChEBI ID CHEBI:63452 (see ChEBI info)
PDQ Closed Trial Search ID 462346
PDQ Open Trial Search ID 462346 (check for NCI PDQ open clinical trial info)
UMLS CUI C0526371

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C35H30N4O4
code C1872
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Midostaurin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1872

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