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Version: 17.06d (Release date: 2017-06-26)
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Valdecoxib (Code C1869)

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Terms & Properties

Preferred Name: Valdecoxib

Definition: A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.

NCI-GLOSS Definition: A substance that is being studied as a treatment for pain and other side effects of cancer therapy. It belongs to the family of drugs called COX-2 inhibitors.

Label: Valdecoxib

NCI Thesaurus Code: C1869 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0913246  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
Bextra
SC 65872
valdecoxib
Valdecoxib
VALDECOXIB

External Source Codes: 
CAS Registry Number 181695-72-7 (see NLM ChemIDplus info)
FDA UNII Code 2919279Q3W
ChEBI ID CHEBI:63634 (see ChEBI info)
PDQ Closed Trial Search ID 38320
PDQ Open Trial Search ID 38320 (check for NCI PDQ open clinical trial info)
UMLS CUI C0913246

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Osteoarthritis; rheumatoid arthritis; dysmenorrhea
Chemical_Formula C16H14N2O3S
code C1869
Contributing_Source FDA
Legacy_Concept_Name Valdecoxib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1869

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