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Version: 17.06d (Release date: 2017-06-26)
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Vatalanib (Code C1868)

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Terms & Properties

Preferred Name: Vatalanib

Definition: An orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and VEGF receptor kinase inhibitors.

Display Name: Vatalanib

Label: Vatalanib

NCI Thesaurus Code: C1868 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0912586  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CGP 79787
PTK787/ZK 222584

External Source Codes: 
CAS Registry Number 212141-54-3 (see NLM ChemIDplus info)
FDA UNII Code 5DX9U76296
NSC Code 719335 (see NCI DTP info)
PDQ Closed Trial Search ID 43530
PDQ Open Trial Search ID 43530 (check for NCI PDQ open clinical trial info)
UMLS CUI C0912586

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H15ClN4
code C1868
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PTK787
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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