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Version: 16.11d (Release date: 2016-11-28)
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Entinostat (Code C1863)

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Terms & Properties

Preferred Name: Entinostat

Definition: A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.

Display Name: Entinostat

Label: Entinostat

NCI Thesaurus Code: C1863 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2743752  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI)
Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl Ester
Entinostat
ENTINOSTAT
entinostat
HDAC inhibitor SNDX-275
MS-275
MS 27-275
N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamide
SNDX-275

External Source Codes: 
CAS Registry Number 209783-80-2 (see NLM ChemIDplus info)
FDA UNII Code 1ZNY4FKK9H
NSC Code 706995 (see NCI DTP info)
PDQ Closed Trial Search ID 38294
PDQ Open Trial Search ID 38294 (check for NCI PDQ open clinical trial info)
UMLS CUI C2743752

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C21H20N4O3
code C1863
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name MS-27-275
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1863

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