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Version: 16.11d (Release date: 2016-11-28)
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Panitumumab (Code C1857)

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Terms & Properties

Preferred Name: Panitumumab

Definition: A human monoclonal antibody produced in transgenic mice that attaches to the transmembrane epidermal growth factor (EGF) receptor. Panitumumab may inhibit autocrine EGF stimulation of tumor cells that express the EGF receptor, thereby inhibiting tumor cell proliferation.

NCI-GLOSS Definition: A human monoclonal antibody that is being used to treat colorectal cancer that has spread to other parts of the body. It is used in patients whose disease has not gotten better during or after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. ABX-EGF binds to the epidermal growth factor receptor (EGFR) and may block tumor cell growth.

Display Name: Panitumumab

Label: Panitumumab

NCI Thesaurus Code: C1857 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879427  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABX-EGF
ABX-EGF, Clone E7.6.3
ABX-EGF Monoclonal Antibody
MoAb ABX-EGF
Monoclonal Antibody ABX-EGF
Panitumumab
PANITUMUMAB
panitumumab
Vectibix

External Source Codes: 
CAS Registry Number 339177-26-3 (see NLM ChemIDplus info)
FDA UNII Code 6A901E312A
PDQ Closed Trial Search ID 37857
PDQ Open Trial Search ID 37857 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879427

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Advanced Stage Colorectal Cancer
code C1857
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_ABX-EGF
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1857

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