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Version: 16.11d (Release date: 2016-11-28)
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BMS-214662 (Code C1856)

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Terms & Properties

Preferred Name: BMS-214662

Definition: A nonsedating benzodiazepine derivative with potential antineoplastic activity. Farnesyltransferase inhibitor BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cells with and without Ras mutations.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.

Display Name: BMS-214662

Label: BMS-214662

NCI Thesaurus Code: C1856 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879424  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine
BMS-214662
FTI BMS 214662

External Source Codes: 
CAS Registry Number 195987-41-8 (see NLM ChemIDplus info)
FDA UNII Code L2U9GFD244
NSC Code 710086 (see NCI DTP info)
PDQ Closed Trial Search ID 37852
PDQ Open Trial Search ID 37852 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879424

Other Properties:
Name Value (qualifiers indented underneath)
code C1856
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name BMS214662
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1856

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