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Version: 17.06d (Release date: 2017-06-26)
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Gefitinib (Code C1855)

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Terms & Properties

Preferred Name: Gefitinib

Definition: An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat certain types of non-small cell lung cancer and is being studied in the treatment of other types of cancer. It is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Display Name: Gefitinib

Label: Gefitinib

NCI Thesaurus Code: C1855 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1122962  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
Gefitinib
gefitinib
GEFITINIB
Iressa
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholin) propoxy]-4-quinazolinamine
ZD1839
ZD 1839

External Source Codes: 
CAS Registry Number 184475-35-2 (see NLM ChemIDplus info)
FDA UNII Code S65743JHBS
ChEBI ID CHEBI:49668 (see ChEBI info)
NSC Code 715055 (see NCI DTP info)
PDQ Closed Trial Search ID 43649
PDQ Open Trial Search ID 43649 (check for NCI PDQ open clinical trial info)
UMLS CUI C1122962

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Non-Small Cell Lung Carcinoma
Chemical_Formula C22H24ClFN4O3
code C1855
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gefitinib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1855

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