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Version: 17.06d (Release date: 2017-06-26)
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Pegfilgrastim (Code C1854)

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Terms & Properties

Preferred Name: Pegfilgrastim

Definition: A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)

NCI-GLOSS Definition: A drug used to increase numbers of white blood cells in patients who are receiving chemotherapy. It is a type of colony-stimulating factor.

Display Name: Pegfilgrastim

Label: Pegfilgrastim

NCI Thesaurus Code: C1854 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1171279  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Filgrastim SD-01
Pegfilgrastim Biosimilar HSP-130
SD-01 sustained duration G-CSF

External Source Codes: 
CAS Registry Number 208265-92-3 (see NLM ChemIDplus info)
FDA UNII Code 3A58010674
NSC Code 725961 (see NCI DTP info)
PDQ Closed Trial Search ID 37807
PDQ Open Trial Search ID 37807 (check for NCI PDQ open clinical trial info)
UMLS CUI C1171279

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chemotherapy-induced neutropenia
Chemical_Formula C3H8NO(C2H4O)n
code C1854
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pegfilgrastim
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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