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Version: 17.06d (Release date: 2017-06-26)
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Micafungin (Code C1850)

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Terms & Properties

Preferred Name: Micafungin

Definition: A semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. Inhibition of this enzyme weakens of the cell wall, thereby leading to osmotic lysis and eventually, fungal cell death.

NCI-GLOSS Definition: An antibiotic/antifungal drug used to treat infection.

Display Name: Micafungin

Label: Micafungin

NCI Thesaurus Code: C1850 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1120386  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FK463
Micafungin
MICAFUNGIN

External Source Codes: 
CAS Registry Number 235114-32-6 (see NLM ChemIDplus info)
FDA UNII Code R10H71BSWG
ChEBI ID CHEBI:600520 (see ChEBI info)
PDQ Closed Trial Search ID 43552
PDQ Open Trial Search ID 43552 (check for NCI PDQ open clinical trial info)
UMLS CUI C1120386

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C56H71N9O23S
code C1850
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Micafungin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1850

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