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Version: 17.06d (Release date: 2017-06-26)
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Aminolevulinic Acid Hydrochloride (Code C1849)

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Terms & Properties

Preferred Name: Aminolevulinic Acid Hydrochloride

Definition: The hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects.

NCI-GLOSS Definition: A drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid hydrochloride is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent.

Display Name: Aminolevulinic Acid Hydrochloride

Label: Aminolevulinic Acid Hydrochloride

NCI Thesaurus Code: C1849 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0876231  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.delta.-Aminolevulinic acid hydrochloride
5-Amino-4-oxopentanoic Acid HCl
5-Amino-4-oxopentanoic Acid Hydrochloride
Alacare
Ameluz
Aminolevulinic Acid HCl
Aminolevulinic Acid Hydrochloride
aminolevulinic acid hydrochloride
AMINOLEVULINIC ACID HYDROCHLORIDE
Delta-Aminolevulinic Acid HCl
Delta-Aminolevulinic Acid Hydrochloride
Levulan
Levulan Kerastick

External Source Codes: 
CAS Registry Number 5451-09-2 (see NLM ChemIDplus info)
FDA UNII Code V35KBM8JGR
NSC Code 18509 (see NCI DTP info)
PDQ Closed Trial Search ID 42648
PDQ Open Trial Search ID 42648 (check for NCI PDQ open clinical trial info)
UMLS CUI C0876231

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H9NO3.ClH
code C1849
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Aminolevulinic_Acid_Hydrochloride
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1849

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