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Version: 17.08d (Release date: 2017-08-28)
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Peginterferon Alfa-2b (Code C1845)

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Terms & Properties

Preferred Name: Peginterferon Alfa-2b

Definition: A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2b protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects, but may also reduce the interferon-mediated stimulation of an immune response. (NCI04)

NCI-GLOSS Definition: A drug used to treat hepatitis C infections. It is also being studied in the treatment and prevention of cancer. It is a cytokine that is modified in the laboratory. It is a type of biological response modifier.

Display Name: Peginterferon Alfa-2b

Label: Peginterferon Alfa-2b

NCI Thesaurus Code: C1845 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796545  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PEG-IFN-a 2b
PEG-IFN Alfa-2b
PEG-interferon alfa-2b
PEG-Interferon Alfa-2b
Peginterferon Alfa-2b
Pegylated Interferon Alpha-2b
PEG Interferon Alpha-2b
PEG Intron
Polyethylene Glycol IFN-A2b
Polyethylene Glycol Interferon Alfa-2b
SCH 54031

External Source Codes: 
CAS Registry Number 215647-85-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:63615 (see ChEBI info)
NSC Code 720033 (see NCI DTP info)
PDQ Closed Trial Search ID 43407
PDQ Open Trial Search ID 43407 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796545

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For chronic hepatitis C; renal cell carcinoma
Chemical_Formula C2H4NO2(C2H4O)n
code C1845
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PEG-Interferon_Alfa-2B
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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