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Version: 17.06d (Release date: 2017-06-26)
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Temsirolimus (Code C1844)

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Terms & Properties

Preferred Name: Temsirolimus

Definition: An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.

NCI-GLOSS Definition: A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein involved in cell division, and may kill cancer cells. It is a type of rapamycin analog and a type of serine/threonine kinase inhibitor.

Display Name: Temsirolimus

Label: Temsirolimus

NCI Thesaurus Code: C1844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1707080  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin
CCI-779
CCI-779 Rapamycin Analog
Cell Cycle Inhibitor 779
Rapamycin Analog
Rapamycin Analog CCI-779
Temsirolimus
temsirolimus
TEMSIROLIMUS
Torisel

External Source Codes: 
CAS Registry Number 162635-04-3 (see NLM ChemIDplus info)
FDA UNII Code 624KN6GM2T
NSC Code 683864 (see NCI DTP info)
PDQ Closed Trial Search ID 43369
PDQ Open Trial Search ID 43369 (check for NCI PDQ open clinical trial info)
UMLS CUI C1707080

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Advanced renal cell carcinoma
Accepted_Therapeutic_Use_For Renal Cell Carcinoma
Chemical_Formula C56H87NO16
code C1844
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CCI-779
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1844

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