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Version: 17.08d (Release date: 2017-08-28)
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BL22 Immunotoxin (Code C1842)

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Terms & Properties

Preferred Name: BL22 Immunotoxin

Definition: A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells.

NCI-GLOSS Definition: A bacterial toxic substance linked to an antibody that attaches to cancer cells and kills them. It belongs to the family of drugs called bacterial immunotoxins.

Label: BL22 Immunotoxin

NCI Thesaurus Code: C1842 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796473  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD22 Recombinant Immunotoxin BL22
BL22 immunotoxin
BL22 Immunotoxin
BL22 Immunotoxin [RFB4(dsFv)-PE38]
Immunotoxin BL22
RFB4(dsFv)-PE38 Immunotoxin

External Source Codes: 
NSC Code 691237 (see NCI DTP info)
PDQ Closed Trial Search ID 43322
PDQ Open Trial Search ID 43322 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796473

Other Properties:
     Name Value (qualifiers indented underneath)
code C1842
Legacy_Concept_Name BL22_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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