|Lepirudin (Code C1839)|
|Terms & Properties|
Preferred Name: Lepirudin
Definition: A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.
NCI-GLOSS Definition: A drug that inhibits blood clotting. It is being studied in cancer treatment.
NCI Metathesaurus Link: C0772394 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||138068-37-8 (see NLM ChemIDplus info)|
|FDA UNII Code||Y43GF64R34|
|PDQ Closed Trial Search ID||43356|
|PDQ Open Trial Search ID||43356 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Amino Acid, Peptide, or Protein|
Additional Concept Data:
|Defined Fully by Roles: No|