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Version: 17.06d (Release date: 2017-06-26)
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Paroxetine Hydrochloride (Code C1837)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Paroxetine Hydrochloride

Definition: The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.

NCI-GLOSS Definition: A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).

Label: Paroxetine Hydrochloride

NCI Thesaurus Code: C1837 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771019  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Hydrochloride
Paroxetine Hydrochloride
paroxetine hydrochloride
PAROXETINE HYDROCHLORIDE ANHYDROUS
Paxil
Paxil CR

External Source Codes: 
CAS Registry Number 78246-49-8 (see NLM ChemIDplus info)
FDA UNII Code 3I3T11UD2S
PDQ Closed Trial Search ID 42793
PDQ Open Trial Search ID 42793 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771019

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Depression
Chemical_Formula C19H20FNO3.HCl
code C1837
Contributing_Source FDA
Legacy_Concept_Name Paroxetine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1837

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