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Version: 17.06d (Release date: 2017-06-26)
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Paroxetine Hydrochloride (Code C1837)

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Terms & Properties

Preferred Name: Paroxetine Hydrochloride

Definition: The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.

NCI-GLOSS Definition: A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).

Label: Paroxetine Hydrochloride

NCI Thesaurus Code: C1837 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771019  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine Hydrochloride
Paroxetine Hydrochloride
paroxetine hydrochloride
Paxil CR

External Source Codes: 
CAS Registry Number 78246-49-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42793
PDQ Open Trial Search ID 42793 (check for NCI PDQ open clinical trial info)
UMLS CUI C0771019

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Depression
Chemical_Formula C19H20FNO3.HCl
code C1837
Contributing_Source FDA
Legacy_Concept_Name Paroxetine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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