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Version: 16.11d (Release date: 2016-11-28)
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Batabulin Sodium (Code C1835)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Batabulin Sodium

Definition: The sodium salt form of batabulin, a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. Batabulin covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis.

Label: Batabulin Sodium

NCI Thesaurus Code: C1835 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0767921  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Fluoro-1-methoxy-4-(pentafluorophenyl-sulfonamido)benzene, Sodium Salt
BATABULIN SODIUM
Batabulin Sodium
T138067 Sodium

External Source Codes: 
CAS Registry Number 195533-98-3 (see NLM ChemIDplus info)
FDA UNII Code G04B77F772
PDQ Closed Trial Search ID 43107
PDQ Open Trial Search ID 43107 (check for NCI PDQ open clinical trial info)
UMLS CUI C0767921

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C13H6F6NO3S.Na
code C1835
Contributing_Source FDA
Legacy_Concept_Name T138067
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1835

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