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Version: 17.06d (Release date: 2017-06-26)
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Cilengitide (Code C1834)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cilengitide

Definition: A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied as an anticancer and antiangiogenesis drug.

Display Name: Cilengitide

Label: Cilengitide

NCI Thesaurus Code: C1834 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0971473  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cilengitide
cilengitide
CILENGITIDE
cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
EMD-121974
EMD 121974

External Source Codes: 
CAS Registry Number 188968-51-6 (see NLM ChemIDplus info)
FDA UNII Code 4EDF46E4GI
NSC Code 707544 (see NCI DTP info)
PDQ Closed Trial Search ID 37844
PDQ Open Trial Search ID 37844 (check for NCI PDQ open clinical trial info)
UMLS CUI C0971473

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H40N8O7
code C1834
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cilengitide
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1834

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