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Version: 17.08d (Release date: 2017-08-28)
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Tegafur-gimeracil-oteracil Potassium (Code C1833)

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Terms & Properties

Preferred Name: Tegafur-gimeracil-oteracil Potassium

Definition: An orally bioavailable fluoropyrimidine antagonist composed of tegafur combined with two modulators of 5-fluorouracil (5-FU) activity, gimeracil and potassium oxonate, in a molar ratio of 1:0.4:1. Tegafur is a prodrug of 5-fluorouracil, an antimetabolite that inhibits thymidylate synthase, DNA synthesis and cell division, and competes with uridine triphosphate, thus inhibiting RNA and protein synthesis. Gimeracil is a reversible inhibitor of dihydropyrimidine dehydrogenase (DPD), the liver enzyme responsible for rapid catabolism of 5-FU into inactive metabolites. Potassium oxonate preferentially localizes in the gut and inhibits the enzyme orotate phosphoribosyl-transferase (OPRT), thereby decreasing activation of 5-FU in the gut and activated 5-FU-related gastrointestinal toxicity.

NCI-GLOSS Definition: A drug that is being studied for its ability to enhance the effectiveness of fluorouracil and prevent gastrointestinal side effects caused by fluorouracil. It belongs to the family of drugs called antimetabolites.

Display Name: Tegafur-gimeracil-oteracil Potassium

Label: Tegafur-gimeracil-oteracil Potassium

NCI Thesaurus Code: C1833 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879262  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS 247616
Tegafur, mixture with Gimeracil and Potassium Oxonate
Tegafur-gimeracil-oteracil Potassium

External Source Codes: 
CAS Registry Number 154239-56-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 43548
PDQ Open Trial Search ID 43548 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 15224197 (see PubMed Primary Reference info)
UMLS CUI C0879262

Other Properties:
     Name Value (qualifiers indented underneath)
code C1833
Contributing_Source CTRP
Legacy_Concept_Name S-1
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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