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Version: 17.06d (Release date: 2017-06-26)
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Rofecoxib (Code C1832)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Rofecoxib

Definition: A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. (NCI04)

NCI-GLOSS Definition: A drug that was being used for pain relief and was being studied for its ability to prevent cancer and to prevent the growth of new blood vessels that tumors need to grow. It is a type of nonsteroidal anti-inflammatory drug and a type of antiangiogenesis agent. Rofecoxib was taken off the market in the U.S. because of safety concerns.

Label: Rofecoxib

NCI Thesaurus Code: C1832 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0762662  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
MK 966
rofecoxib
Rofecoxib
ROFECOXIB
Vioxx

External Source Codes: 
CAS Registry Number 162011-90-7 (see NLM ChemIDplus info)
FDA UNII Code 0QTW8Z7MCR
ChEBI ID CHEBI:8887 (see ChEBI info)
NSC Code 720256 (see NCI DTP info)
PDQ Closed Trial Search ID 38568
PDQ Open Trial Search ID 38568 (check for NCI PDQ open clinical trial info)
UMLS CUI C0762662

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Pain; dysmenorrhea; osteoarthritis; rheumatoid arthritis
Chemical_Formula C17H14O4S
code C1832
Contributing_Source FDA
Legacy_Concept_Name Rofecoxib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1832

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