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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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RevM10 Gene (Code C18318)

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Terms & Properties

Preferred Name: RevM10 Gene

Definition: RevM10 is a dominant-negative mutant of HIV-1 Rev gene, which encodes an RNA-binding protein involved in nuclear trafficking of unspliced viral mRNAs. The fact that Rev is essential for HIV-1 replication makes it an attractive target for antiviral approaches. Based on the notion of intracellular immunization, in vitro studies that introduce RevM10 gene into stem cells have demonstrated its ability to combat HIV-1 infection in human hematopoietic cells.

NCI-GLOSS Definition: An antiviral gene being studied for treatment of cancer in patients who have HIV, the virus that causes AIDS.

Label: RevM10 Gene

NCI Thesaurus Code: C18318 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796697  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
RevM10 gene
RevM10 Gene

External Source Codes: 
PDQ Closed Trial Search ID 43534
PDQ Open Trial Search ID 43534 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796697

Other Properties:
     Name Value (qualifiers indented underneath)
code C18318
Legacy_Concept_Name RevM10_Gene
Semantic_Type Gene or Genome

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C18318

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