|RevM10 Gene (Code C18318)|
|Terms & Properties|
Preferred Name: RevM10 Gene
Definition: RevM10 is a dominant-negative mutant of HIV-1 Rev gene, which encodes an RNA-binding protein involved in nuclear trafficking of unspliced viral mRNAs. The fact that Rev is essential for HIV-1 replication makes it an attractive target for antiviral approaches. Based on the notion of intracellular immunization, in vitro studies that introduce RevM10 gene into stem cells have demonstrated its ability to combat HIV-1 infection in human hematopoietic cells.
NCI-GLOSS Definition: An antiviral gene being studied for treatment of cancer in patients who have HIV, the virus that causes AIDS.
Label: RevM10 Gene
NCI Metathesaurus Link: C0796697 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||43534|
|PDQ Open Trial Search ID||43534 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Gene or Genome|
Additional Concept Data:
|Defined Fully by Roles: No|