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Version: 17.06d (Release date: 2017-06-26)
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Semaxanib (Code C1831)

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Terms & Properties

Preferred Name: Semaxanib

Definition: A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.

NCI-GLOSS Definition: A substance that has been studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and tyrosine kinase inhibitors.

Display Name: Semaxanib

Label: Semaxanib

NCI Thesaurus Code: C1831 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1135174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-
Semaxanib
SEMAXANIB
semaxanib
Semoxind
SU5416
Sugen 5416
SU 5416

External Source Codes: 
CAS Registry Number 194413-58-6 (see NLM ChemIDplus info)
FDA UNII Code 71IA9S35AJ
NSC Code 696819 (see NCI DTP info)
PDQ Closed Trial Search ID 43310
PDQ Open Trial Search ID 43310 (check for NCI PDQ open clinical trial info)
UMLS CUI C1135174

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H14N2O
code C1831
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Semaxanib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1831

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